Powerful Skin whitening Plus +11x(Extra Strong)
This program is for those people that want a skin lightening in a natural.
with our work of frequencies and energies will help you get your dream skin, and all in a safe way which is even better. Our programs are free of any side effects, because all negative substances are demagnetized while we are doing them.
Skin whitening, also known as skin lightening and skin bleaching, is the practice of using chemical substances in an attempt to lighten the skin or provide an even skin color by reducing the melanin concentration in the skin.
Mechanism of action
Skin whitening agents work by reducing the presence of melanin pigment in the skin. To accomplish this, there are several possible mechanisms of action
Inhibition of the activity of tyrosinase: The catalytic action of tyrosinase is inhibited by the skin whitening agent.
Inhibition of the expression or activation of tyrosinase: The ant melanogenic agent causes less tyrosinase to be generated or prevents tyrosinase from being activated to its functional form.
Scavenging of the intermediate products of melanin synthesis.
Preventing the transfer of melanosomes to keratinocytes.
Directly destroying existing melanin.
Destroying melanocytes.
Inhibition of tyrosinase
Further information: Enzyme inhibitor
Upregulation of tyrosinase caused by tyrosinase inhibitors. Several skin whitening agents, including tyrosinase inhibitors, have been found to cause an increase in the expression of tyrosinase, which by itself would increase melanin synthesis.
Microphthalmia-associated transcription factor (MITF) is the master transcription factor that controls the expression of TYR, TRP1 and TRP2, MART1, PMEL17, and many other important proteins involved in the function of melanocytes.[notes 1] Downregulation of MITF decreases melanogenesis and is a mechanism of action of some skin whitening agents. Various signaling pathways and genetic mutations influence the expression of MITF.
MC1R receptor and cAMP
The melanocortin 1 receptor (MC1R) is a transmembrane and G-protein coupled receptor expressed in melanocytes. MC1R is an important target for the regulation of melanogenesis.[41][42][38] Agonism of MC1R increases the ratio of eumelanin to pheomelanin and increases the generation of melanin overall.
The MC1R and cAMP signaling pathway starts with the activation of MC1R, which causes activation of adenylyl cyclase (AC), which produces cyclic adenosine monophosphate (cAMP), which activates protein kinase A (PKA), which activates by protein phosphorylation cAMP response element-binding protein (CREB), which upregulates MITF, of which CREB is a transcription factor.
Alpha-melanocyte stimulating hormone (α-MSH), beta-melanocyte stimulating hormone (β-MSH), and adrenocorticotropic hormone are endogenous agonists of MC1R.[40]:1175 Agouti signaling protein (ASIP) appears to be the only endogenous antagonist of MC1R. Synthetic MC1R agonists have been designed, such as the peptides afamelanotide and melanotan II.
Mutations of the MC1R gene correlate and are at least partially responsible for red hair, white skin, and an increased risk for skin cancer in some individuals.[41][44][42][45][46][47][40]:1175
Transfer of melanosomes
See also: human skin § Structure, and epidermis
Within the skin, melanocytes are present in the basal layer of the epidermis; from these melanocytes originate dendrites that reach keratinocytes.[notes 3]
Melanosomes along with the melanin they contain are transferred from melanocytes to keratinocytes when keratinocytes are low in the epidermis.[notes 4] Keratinocytes carry the melanosomes with them as they move towards the surface. Keratinocytes contribute to skin pigmentation by holding the melanin originated in melanocytes and inducing melanogenesis through chemical signals directed at melanocytes.[notes 2] The transfer of melanosomes to keratinocytes is a necessary condition for the visible pigmentation of the skin.[48] Blocking this transfer is a mechanism of action of some skin whitening agents.
The protease-activated receptor 2 (PAR2) is a transmembrane and G-protein coupled receptor expressed in keratinocytes and involved in melanocyte transfer. Antagonists of PAR2 inhibit the transfer of melanosomes and have skin whitening affects, while agonists of PAR2 have the opposite effect.
Destroying melanocytes
Some compounds are known to destroy melanocytes; this mechanism of action is often used to remove the remaining pigmentation in cases of vitiligo.
Main Benefits of this program:
- Skin whitening (Whole body)
- bleaching of the harmonica (whole body)
- destroying melanin layer by layer with total security
- accelerated skin restructuring
- brighter regrow
Use Once a day is enough